The Wistar Institute has an upcoming opening in the Imaging Shared Resource (i.e., “Core” or “Facility”) for the Managing Director position. The successful candidate will overlap with the current Managing Director for a period of six months to ensure a seamless transition. The Managing Director will lead the day-to-day operations of the Imaging Shared Resource of The Wistar Institute, including management of the Facility staff. The Core provides all Wistar investigators with access to traditional and advanced optical systems capable of imaging complex cellular structures and elucidating the temporal and spatial organization of regulatory events within cells, tissues, and organisms. The Facility also offers expert technical assistance with advanced image analysis solutions. The Managing Director will be expected to advise and coordinate work/facilitate projects with clients with the assistance of the Core's staff and in collaboration with the Core's Scientific Director
Duties and Responsibilities
- Perform and oversee imaging services for fixed and live specimens on a variety of microscopy and specialty imaging platforms, including Nikon NiE, TiE, 80i, TE2000, and TE300 widefield microscopy systems, a Leica Mica Widefocal automated microscope, Leica SP8 WLL and Stellaris 8 WLL confocal laser scanning microscopes, a Stellaris 8 3X TauSTED super-resolution confocal microscope, a Leica SP8 2-photon intravital microscope, a Hamamatsu S60 Nanozoomer whole slide scanner, and traditional photographic techniques with a Nikon Z6II digital camera system.
- Perform and assist with multidimensional analysis of acquired images using a variety of software packages, including Nikon Elements AR with AI module, Leica LAS-X, Leica Aivia, SVI Huygens deconvolution software,e and Image J (FIJI).
- Provide training for Wistar technical and research staff in the use of facility instrumentation and software.
- Coordinate with the Co-Managing Director to support pre-clinical imaging using a Revvity IVIS SpectrumCT, Revvity Vega high-throughput ultrasound, and whole-body or targeted radiotherapy using an Xstrahl Small Animal Radiation Research Platform (SARRP).
- Create, train, and assist with publication-quality figures of scientific images.
- Oversee daily operations of the facility and maintain equipment and infrastructure.
- Supervise and train core facility research assistant(s).
- Maintain a working knowledge of all equipment and technical aspects of the services offered by the Facility.
- Maintain “state of the art” capabilities of the equipment and services provided by the facility and develop new techniques as needed.
- Provide up-to-date facility records and preparation of monthly reports.
- Manage iLab, the software tool for Core Facility Operation and associated billing events/financial management for imaging instrumentation.
- Communicate with investigators to fully understand their imaging needs, inform them of the capabilities of the core, and help integrate the facility with their existing research programs.
- Actively solicits users and maximizes the efficiency of operation and utilization of the facility.
- Coordinate with Wistar faculty to identify gaps in current imaging instrumentation and develop proposals to support the acquisition of new equipment to support those needs.
- Develop working relationships with colleagues in nearby facilities for information sharing and mutual support.
A Bachelor’s or Master’s degree in Biology, Physics, Bioengineering, or a related scientific discipline with 5 to 7 years of experience or a PhD in Biology, Physics, Bioengineering, or a related scientific discipline is required.
At least 10 years of experience in an imaging core facility, including operation of multi-dimensional, brightfield, and fluorescence microscopes using widefield and confocal systems with live and fixed samples. Experience with advanced confocal techniques, including super-resolution (STED), Fluorescence Lifetime Imaging (FLIM), Förster resonance energy transfer (FRET), and others, is desired. Experience with 2-photon intravital imaging is a plus. Advanced knowledge of image analysis platforms and computer hardware integration with high content and high throughput systems is strongly desired. Traditional photographic skills for macro to full-sized subjects is also preferred.
The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources to its faculty and staff that enable them to conduct cutting-edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities.
We offer a competitive salary and an excellent benefits package.
For more information about The Wistar Institute, visit our website at www.wistar.org.
It is the policy of the Institute to provide equal employment opportunities to all individuals regardless of race, citizenship, ethnicity, color, creed, religion, marital status, national origin, ancestry, sex, age, veteran status, mental or physical disability (including HIV and AIDS), pregnancy, caregiver status, domestic or sexual violence victim status, sexual orientation, gender identity and expression, or on the basis of genetic information, or any other characteristic protected by federal, state, or local law, with respect to all terms and conditions of employment.
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