ROLE SUMMARY
Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. At the core of this mission is our Research and Development organization, where advanced science and technology are transformed into the therapies and vaccines that matter most. Whether you're working in discovery sciences, ensuring drug safety and efficacy, or supporting clinical trials, you’ll be applying cutting-edge design and process development capabilities to accelerate innovation and deliver best-in-class medicines to patients around the world.
As a Principal Scientist, you will play a pivotal role in our operations —where every action reflects our unwavering commitment to quality. Recognized as a technical authority and key scientific contributor, you’ll bring deep expertise to therapeutic areas and represent the department on cross-functional teams.
In this role, you’ll lead qualitative and quantitative analyses of organic and inorganic compounds to uncover their chemical and physical properties throughout the drug product development lifecycle. You’ll set strategic objectives, plan resource needs, and guide your project team with confidence and clarity.
Your scientific judgment will be essential as you adapt and refine methodologies, drawing on your experience to solve complex challenges. You’ll also mentor and inspire team members, fostering growth and innovation.
Above all, your forward-thinking mindset and passion for science will help Pfizer reach new milestones—delivering life-changing medicines to patients around the world.
To do this, you will drive analytical strategy by collaborating with project teams. You will develop chromatographic and dissolution methods in support of drug development and utilize analytical project knowledge to influence control strategy decisions for your program. You will apply your expertise in separations and chromatography as well as other analytical methodologies (e.g. dissolution, spectroscopy, mass spectrometry, and NMR) to enable drug product development.
ROLE RESPONSIBILITIES
As a Project Lead, you will play a critical role in shaping analytical strategies that support pharmaceutical drug development across all phases. Your responsibilities will include:
- Designing and executing analytical approaches to support manufacturing process development.
- Developing, validating, and transferring analytical methods to ensure robust and reliable data generation.
- Planning and implementing stability studies to understand degradation pathways and establish shelf-life parameters.
- Creating impurity control strategies to ensure product quality and regulatory compliance.
You will conduct laboratory work and oversee the planning, execution, and review of experiments performed by other scientists in a collaborative, matrixed environment.
This role requires close collaboration with cross-functional teams to identify and apply the most effective analytical techniques, including the use of computational modeling, predictive tools, and data visualization platforms.
You will critically evaluate scientific data to draw clear conclusions, guide future work, and communicate findings through presentations, technical reports, and other media.
As a subject matter expert, you will assess and implement new analytical technologies and instrumentation, while mentoring junior scientists to foster technical growth and innovation.
Additionally, you will contribute to regulatory submissions by authoring relevant sections of the quality modules, ensuring alignment with global standards and expectations.
BASIC QUALIFICATIONS
- PhD in Analytical Chemistry or related field, with 4 or more years of R&D experience; or MSc with 9 or more years of R&D experience.
- Demonstrated oral and written communication skills, including visualization of data, presentations and authoring technical articles.
- Demonstrated ability to meet timelines and interact with multi-disciplinary teams.
- Demonstrated ability to learn new techniques and solve complex analytical problems.
- Attention to detail, strong organizational skills, and effective interpersonal and communication skills are required.
- Proficient with a wide variety of software and information systems.
PREFERRED QUALIFICATIONS
- Working knowledge and the ability to operate analytical techniques such as HPLC-MS, GC-MS, spectroscopy, and physical techniques such as particle size and dissolution that are commonly used for the characterization of pharmaceutical substances and products is desired.
- Candidate demonstrates a breadth of diverse leadership experiences and capabilities including the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
PHYSICAL/MENTAL REQUIREMENTS
This role requires ability to perform mathematical calculations, as well as data analysis. Ability to work in a laboratory setting.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
This role requires adherence to standard operating procedures. It could also require some travel.
ADDITIONAL INFORMATION
Relocation support available
Work Location Assignment: On premise
Work Location Assignment: On premise
Last date to apply: September 2nd, 2025
The annual base salary for this position ranges from $102,900.00 to $171,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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