Medical Director

THE COMPANY
89bio is a clinical-stage biopharmaceutical company dedicated to the development of best-
in-class therapies for patients with liver and cardiometabolic diseases who lack optimal
treatment options. The company is focused on rapidly advancing its lead candidate,
pegozafermin, through Phase 3 clinical development for the treatment of metabolic
dysfunction-associated steatohepatitis (MASH) and severe hypertriglyceridemia (SHTG).
Pegozafermin is a specifically engineered, potentially best-in-class fibroblast growth factor
21 (FGF21) analog with unique glycoPEGylated technology that optimizes biological activity
through an extended half-life. The company is headquartered in San Francisco.

SPECIAL ADVISORY
The FTC has an advisory out on the domain 89biocareers.com if you are contacted by any
group using a similar, but not our exact domain 89bio.com, please Report any Scams.

THE ROLE
Reporting to the Executive Medical Director the Medical Director will be primarily responsible
for providing medical and scientific expertise to support our Phase 3 clinical MASH program
primarily focused on cirrhosis. The Medical Director will serve as a key clinical leader working
cross-functionally with Clinical Operations, Regulatory Affairs, Pharmacovigilance,
Biometrics, and external partners to ensure the integrity, safety, and success of our late-stage
trials.

THE RESPONSIBILITIES

• Serve as one of the Medical Monitors for ongoing Phase 3 trials, overseeing medical
  oversight, safety signal detection, and protocol compliance.
• Provide clinical and scientific input into trial design, protocols, amendments, and study
  conduct documentation (e.g., IBs, ICFs, SAPs).
• Participate in clinical data review, interpretation, and decision-making, including
  support for database locks, interim analyses, and regulatory submissions.
• Collaborate with the Safety/Pharmacovigilance team to monitor and assess adverse
  events and serious adverse events, ensuring timely escalation and communication.
• Lead or participate in Clinical Study Team (CST) meetings and contribute to cross-
  functional program team discussions.
• Review and contribute to regulatory documents, including briefing books, INDs, NDAs,
  and responses to health authorities.
• Provide medical expertise in interactions with CROs, investigators, DSMBs, and KOLs
  to support trial execution and data integrity.
• Remain current on therapeutic trends, competitive landscape, and emerging data in
  MASH, liver fibrosis, and metabolic diseases.
• Requires successful cross-collaboration with groups such as clinical science, clinical
  operations, regulatory, biometrics, safety and other functions as needed throughout the
  organization
• Requires travel to sites, scientific meetings, CRO’s and other meetings as needed (25-
  30%.

THE QUALIFICATIONS

• MD or equivalent medical degree is required; board certification in Gastroenterology,
  Hepatology, or Internal Medicine with a focus on metabolic diseases preferred.
• At least 5–8 years of industry experience in clinical development or medical
  monitoring, ideally with late-phase experience in liver/metabolic diseases (MASH and
  cirrhosis specifically).
• Demonstrated leadership in Phase 2 or 3 clinical trials, including protocol design,
  medical oversight, and regulatory engagement.
• Experience working within or overseeing global, multi-center trials and collaborating
  with CROs and external stakeholders.
• Deep understanding of GCP, ICH guidelines, FDA/EMA regulations, and global drug
  development processes.
• Excellent communication, critical thinking, and collaborative skills; ability to translate
  clinical data into strategic insights.

SALARY & LEVEL
89bio considers a range of factors when determining salary and level. These considerations
mean actual salary and level may vary. The expected salary range for this position based on
the primary location for this position in Northern California is $263,000 – $315,000.
89bio’s role/level assessment approach involves assessing candidates during the interview
process before confirming the level/title designation. The level assessment is considered on a
case-by-case basis. Offer and level is based on factors such as: education, experience,
qualifications, geographic location, transferable skills, licenses/certifications and other job-
related factors permitted by law.

THE PERKS

• Competitive health insurance coverage
• Generous PTO allowance
• 401k match
• Employee Stock Purchase Plan (ESPP)
• Commuter Benefits
• Women's forum / mentoring
• Office based in the heart of San Francisco, near plenty of shops and restaurants
• Fun opportunities to engage with co-workers in-person and remotely

CONDITIONS OF EMPLOYMENT

• Background investigations are required for all positions by 89bio, consistent with
  applicable law.

All qualified applicants will receive consideration for employment without regard to race, sex, color,
religion, sexual orientation, gender identity, national origin, protected veteran status, or based on
disability.
89bio is committed to the full inclusion of all qualified individuals. As part of this commitment, 89bio will
ensure that persons with disabilities are provided reasonable accommodations for the hiring process,
and/or to perform essential job functions where the requested accommodation does not impose an undue
hardship.
Notice to Recruiters: To protect the interest of all parties, 89bio does not accept unsolicited resumes and
we ask that employees, hiring managers and executives not be contacted directly. All recruitment is
managed through the 89bio Talent Acquisition Team.