Research Specialist A/ Research Specialist B - CRISPR Immune Systems, Penn Biology

Research Specialist A/ Research Specialist B - CRISPR Immune Systems, Penn Biology Research Specialist A The Santiago-Frangos lab seeks a motivated and enthusiastic scientist to work in a multidisciplinary team on cutting edge research that determines how bacterial immune systems (e.g. CRISPR) function and that repurposes these mechanistic insights for biotech applications. More information about our science can be found at https://web.sas.upenn.edu/sanfrango-lab/. The Research Specialist will be eager to engage in independent and collaborative research projects in the areas of biochemistry, structural biology, microbiology, and may involve work with yeast and/or mammalian cell culture. The selected candidate will gain knowledge in experimental design, execution and analysis under the guidance of the Principal Investigator. Previous undergraduate mentees have been awarded the national Goldwater Scholarship and have gained admission to top PhD and MD/PhD programs (Berkely, Washington University School of Medicine). The research specialist will work in an environment that is team oriented, with creative and enthusiastic scientists. The candidate will undertake several administrative duties in the lab but is expected to dedicate 80% of their time towards research.

• Design, troubleshoot, and carry out experiments (e.g., PCR; protein expression & purification using affinity, ion exchange, hydrophobicity or IMAC chromatography; in vitro activity assays with new enzymes; analyze fluorescent reactions separated on polyacrylamide gels; cryo-EM sample preparation; cryo-EM data analysis; phage plaque assays).
• Data analysis and presentations. Generate figures and progress reports describing research results.
• Keep a detailed Electronic Lab Notebook.
• Training and management of incoming lab members as needed.
• Purchasing for the lab, equipment service & maintenance, lab maintenance and organization, lab cleaning, monitor supplies. Cleaning and autoclaving laboratory glassware. Maintain lab stocks and edit lab database information.
• Stay up to date on relevant literature.
• Assisting with generating SOP protocols and lab records; oversee biosafety, fire safety, chemical safety and additional safety protocols.
• Shipping/receiving stocks and reagents - liaison with collaborators.

• Independently troubleshoot experimental issues and lead complex experimental design.
• Contribute more substantially to data interpretation, and writing sections of manuscripts.
• Take the lead in training and mentoring junior lab members.
• Oversee lab safety and compliance more directly and develop standard operating procedures (SOPs).
• Manage communications and logistics with collaborators and vendors with minimal oversight.

• Bachelor of Science and 0 to 1 year of experience or equivalent combination of education and experience is required.
• Prior experience in either protein biochemistry, protein purification or structural biology is preferred.
• Can work independently, and well with others, has strong communication skills (verbal and written).
• Strong multitasking abilities and an extremely high-level of reliability and dependability.
• Excellent organizational record keeping skills are required.

• Bachelor’s degree in a scientific field and 1 to 3 years of relevant experience, or equivalent combination of education and experience is required.
• Demonstrated expertise in protein biochemistry, purification, or structural biology.
• Proven ability to independently plan, execute, and troubleshoot experiments, lead aspects of lab operations, and contribute significantly to manuscripts and project development.

Philadelphia, Pennsylvania School of Arts and Sciences $44,500.00 - $58,000.00 Annual Rate

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