Molecular Histotechnologist

About Tonix*

Tonix is a biopharmaceutical company, publicly traded on NASDAQ (ticker: TNXP). The Company is focused on commercializing, developing, discovering and licensing therapeutics to treat and prevent human disease. Tonix markets Zembrace® SymTouch® (sumatriptan injection) 3 mg and Tosymra® (sumatriptan nasal spray) 10 mg. Zembrace SymTouch and Tosymra are each indicated for the treatment of acute migraine with or without aura in adults. Tonix’s development portfolio is composed of central nervous system (CNS), rare disease, immunology and infectious disease product candidates. Tonix’s CNS development portfolio includes both small molecules and biologics to treat pain, neurologic, psychiatric and addiction conditions. The Company’s immunology portfolio includes biologics to address organ transplant rejection, autoimmunity, and cancer. Tonix’s infectious disease pipeline consists of a vaccine in development to prevent smallpox and monkeypox, which also serves as the live virus vaccine platform or recombinant pox vaccine platform for other infectious diseases.

Position Overview

Tonix Pharmaceuticals is seeking a highly experienced and innovative histotechnologist to provide a full spectrum of histology and pathology techniques at our Research and Development Center in support of a growing portfolio of therapeutics in infectious diseases, immunology, oncology, and central nervous system disease. This position will play a key role in developing in-house capabilities in routine histology and molecular pathology techniques using standard and specialized microscopy techniques and will advise

on feasibility and applicability of these techniques for ongoing and future research protocols. The ideal candidate will have extensive experience in routine and specialized molecular histologic techniques, gross necropsy and sample preparation, and animal research under high biocontainment conditions.

Key Responsibilities

• Gross Necropsy and Tissue Collection
• Assist with or independently perform gross necropsies on various laboratory animal species in ABSL-2 and ABSL-3 conditions
• Collect fresh and fixed tissues for histologic, molecular, or electron microscopy techniques

Tissue Processing and Embedding, Microtomy, Slide Preparation

• Process tissue samples using automated or manual methods
• Embed tissues in paraffin blocks for sectioning
• Section tissues at appropriate thicknesses using microtome or cryostat
• Mount sections on glass slides or other media as appropriate for follow-on analytical technique

Staining Techniques

• Perform hematoxylin and eosin (H&E) staining, as well as routine histochemical stains on prepared slides
• Develop and perform Immunohistochemistry (IHC) staining using standard chromogen- or fluorescent-labeled antibodies to detect specific antigens within tissue sections
• Develop and perform In Situ Hybridization (ISH), including fluorescence ISH (FISH) to localize nucleic acid sequences within tissue sections
• Performs digital whole slide image scanning and archiving

Quality Control and Documentation

• Report pathology data and enter select pathology findings in electronic data capturing systems
• Maintain accurate records of procedures and results
• Optimize and validate staining protocols
• Prepare control slides and ensure analytical result integrity
• Perform operator level equipment preventive maintenance and calibration on assigned equipment

Collaboration and Training

• Work closely with collaborators, investigators, technicians, and pathologists to maximize data diagnostic value and accuracy of pathology techniques
• Provide training and technical guidance for investigators and staff in appropriate necropsy and histological techniques

Qualifications

• Associate or bachelor’s degree in histotechnology or related field
• ASCP certification (HT or HTL) preferred
• Minimum 6 years’ experience in a high-throughput histology lab, with minimum 3 years’ experience with immunohistochemistry and in situ hybridization; demonstrated proficiency in microtomy, histochemical staining, and molecular techniques
• Experience in supporting GLP and non-GLP preclinical research and animal model development in pharmaceutical industry or government research laboratories
• Experience in maintaining written and electronic laboratory records
• Strong communication and organizational skills, ability to work independently and as an integral part of a research team

Recruitment & Staffing Agencies

Tonix does not accept agency resumes unless contacted directly by internal Tonix Talent Acquisition. Please do not forward resumes to Tonix employees or any other company location; Tonix is not responsible for any fees related to unsolicited resumes.

Compensation & Benefits

Annualized base salary ranges from $70,000 to $120,000 plus target incentive; actual salaries will vary and may be above or below this range commensurate with several factors including experience, education, training, location, and merit.

Tonix provides a comprehensive compensation and benefits package which includes:

• Medical, Dental & Vision Insurance, Basic and Voluntary Life and AD&D Insurance, Short- and Long-Term Disability Insurance, Flexible Spending Accounts, Health Savings Account, and Employee Assistance Programs
• Pet Insurance
• Retirement Savings 401k with company match and annual discretionary stock options
• Generous Paid Time Off, Sick Time, & Paid Holidays
• Career Development and Training

Tonix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, genetics, or any other characteristic protected by law. In addition to federal law requirements, Tonix complies with applicable state and local laws governing nondiscrimination in employment. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfers, leaves of absence, compensation, and training. Tonix expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic, information, disability, veteran status, or any other characteristic protected by law.