Researcher 5 - Vascular/Brain Aging and Alzheimer’s Disease
About the Job:
How lipids and lipoproteins contribute to vascular and brain aging and Alzheimer’s disease (AD) is unclear. We have a Researcher 5 or higher position immediately available in the lab of Danni Li (Department of Lab Medicine and Pathology, University of Minnesota) to investigate lipids and lipoproteins in two important AD research projects funded by the National Institute on Aging.
First, we will conduct a large-scale analysis of already-collected blood samples from older adults to examine plasma components known as lipoproteins. This study will uncover previously unknown associations of the proteins and lipids found within plasma lipoproteins with AD development and progression, allowing us to identify new AD biomarkers related to the vascular system for further strategy development to prevent or slow the progression of AD or AD-related dementias. Second, inheritance of the apolipoprotein (APO) E4 gene is the most potent genetic risk factor identified to date for late-onset AD. We will determine the impact of mitochondrial lipidomic dynamics and its interaction with different APOE isoforms on brain aging and AD progression. We will also identify novel molecular targets and pathways as diagnostic biomarkers/or for therapeutic development to block pathogenic brain aging and AD.
This position will be primarily responsible for developing and optimizing advanced proteomics and lipidomics methods (e.g., based on mass spectrometry) and applying them to investigate our research questions. This position will provide an excellent opportunity for training in bioinformatics and biostatistics, including analyzing large-scale proteomics and other “omics” data using programming languages (e.g., R) and correlating data with the outcomes available. This person will also assist the Principal Investigator with data interpretation and manuscript preparation.
- An advanced degree in chemistry or a biological-related field with at least one year of laboratory experience
- Excellent communication skills – verbal and written
- Excellent interpersonal skills and ability to work collaboratively with others
- Experience with mass spectrometry
- Experience with biostatistics and bioinformatics
Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume.
Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section.
To request an accommodation during the application process, please e-mail [email protected] or call (612) 624-UOHR (8647).
The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds.
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Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment.
Please note: All employees at the University of Minnesota are required to comply with the University’s Administrative Policy: COVID-19 Vaccination and Safety Protocol by either providing proof of being fully vaccinated on their first day of employment, or complete a request for an exemption for medical exemption or religious reasons. To learn more please visit: https://safe-campus.umn.edu/return-campus/get-the-vax
The University of Minnesota, Twin Cities (UMTC)
The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.
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